2,4-Dinitrochlorobenzene Properties

Melting point:

48-50 °C(lit.)

Boiling point:

315 °C(lit.)

Density 

314

vapor pressure 

1 hPa (106 °C)

refractive index 

1.5857

Flash point:

367 °F

storage temp. 

Store below +30°C.

solubility 

alcohol: very slightly soluble (cold)(lit.)

form 

Crystalline Mass, Chunks or Crystals and Powder

color 

Yellow to brown

explosive limit

1.9-22%(V)

Water Solubility 

insoluble

Merck 

14,2136

BRN 

613161

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, ammonia. Reacts violently with hydrazine hydrate.

2,4-Dinitrochlorobenzene Chemical Properties,Uses,Production

Chemical Properties

yellow crystals with an almond odour

Uses

1-Chloro-2,4-dinitrobenzene is a benzene derivative and is used in biochemical research as a substrate for glutathione S-transferase.

Definition

ChEBI: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.

General Description

Pale yellow needles, almond odor.

Reactivity Profile

Self-reactive, [Halpern, Chem. and Eng. News, 29:2666(1951)]. The mixture of 2,4-Dinitrochlorobenzene with hydrazine hydrate caused a violent reaction.

Hazard

Toxic by ingestion, inhalation, and skin absorption. Combustible. Upper explosive limit 22%. A skin irritant.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Contact allergens

This substance is one of the strongest primary skin irritants known, and a universal contact allergen. Occupational dermatitis has been reported, but current use is decreasing or performed with completely closed systems. DNCB is sometimes used for topical treatment of alopecia areata, severe warts, and cutaneous metastasis of malignant melanoma

Safety Profile

Poison by skin contact and intraperitoneal routes. Moderately toxic by ingestion. A severe human skin and eye irritant. Acts as a primary irritant as well as a sensitizer of skin. An allergen. Mutation data reported. Combustible when exposed to heat or flame. A moderate explosion hazard when exposed to flame, sparks, heated to 1 50°, or when shocked in a sealed container. Explosive reaction with ammonia at 17O℃/40 bar. To fight fire, use CO2, dry chemical. Reacts violently with hydrazine sulfate or hydrazine hydrate. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS.

Purification Methods

Usually it is recrystallised from EtOH or MeOH. It has also been crystallised from Et2O, *C6H6, *C6H6/pet ether or isopropyl alcohol. A preliminary purification step is to pass its solution in *benzene through an alumina column. It has also been purified by zone refining. It exists in three forms: one stable and two unstable. The stable form crystallises as yellow needles from Et2O, m 51o, b 315o/760mm with some decomposition, and is soluble in EtOH. A labile form also crystallises from Et2O, m 43o, and is more soluble in organic solvents. The second labile form has m 27o. [Hoffman & Dame, J Am Chem Soc 41 1015 1919, Welsh J Am Chem Soc 63 3276 1941, J Chem Soc 2476 1957, Beilstein 5 IV 744.]                     

SAFETY

• Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06,GHS08,GHS09,GHS07
Signal word	Danger
Hazard statements	H331-H400-H302-H335-H341-H370-H301+H331-H310-H315-H317-H318-H373-H410
Precautionary statements	P201-P202-P260-P262-P264-P270-P271-P272-P301+P312+P330-P302+P352+P310+P361+P364-P304+P340+P312-P305+P351+P338+P310-P307+P311-P391-P403+P233-P405-P501-P261-P273-P280-P301+P310-P302+P350-P305+P351+P338-P280h-P304+P340-P501a
Hazard Codes	T,N
Risk Statements	23/24/25-33-50/53-43-41-38
Safety Statements	28-36/37-45-60-61-28A-24
RIDADR	UN 3441 6.1/PG 2
WGK Germany	2
RTECS	CZ0525000
Autoignition Temperature	464 °C
Hazard Note	Toxic
TSCA	Yes
HSCode	2904 99 00
HazardClass	6.1
PackingGroup	II
Toxicity	LD50 orally in Rabbit: 640 mg/kg LD50 dermal Rabbit 130 mg/kg

NFPA 704

Diamond	Hazard	Value	Description
1 3 4	Health	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
	Flammability	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
	Instability	4	Readily capable of detonation or explosive decomposition at normal temperatures and pressures (e.g. nitroglycerin,chlorine dioxide, nitrogen triiodide)
	Special

(NFPA, 2010)